Streamlining USDA Regulation of Gene Editing to Benefit US Agriculture

Technologies To Benefit Agriculture and Wildlife (Part 5 of 9)

Negative Feedback Regulation of HIV-1 by Gene Editing Strategy

The CRISPR/Cas9 gene editing method is comprised of the guide RNA (gRNA) to target a specific DNA sequence for cleavage and the Cas9 endonuclease for introducing breaks in the double-stranded DNA identified by the gRNA. Co-expression of both a multiplex of HIV-1-specific gRNAs and Cas9 in cells results in the modification and/or excision of the segment of viral DNA, leading to replication-defec...

Big interdisciplinarity to address climate change and agriculture: Lessons from three USDA Coordinated Agricultural Projects

Sanford D. Eigenbrode is a professor of entomology and director of Regional Approaches to Climate Change for Pacific Northwest Agriculture, University of Idaho, Moscow, Idaho. Lois Wright Morton is a professor of sociology and director of Climate and Corn-based Cropping Systems Coordinated Agricultural Project, College of Agriculture and Life Sciences, Iowa State University, Ames, Iowa. Timothy...

Cost-benefit theory and optimal design of gene regulation functions.

Cells respond to the environment by regulating the expression of genes according to environmental signals. The relation between the input signal level and the expression of the gene is called the gene regulation function. It is of interest to understand the shape of a gene regulation function in terms of the environment in which it has evolved and the basic constraints of biological systems. He...

Adaptation to Climate Change: Evidence from US Agriculture

Understanding the potential impacts of climate change on economic outcomes requires knowing how agents might adapt to a changing climate. We exploit large variation in recent temperature and precipitation trends to identify adaptation to climate change in US agriculture, and use this information to generate new estimates of the potential impact of future climate change on agricultural outcomes....